Searchable abstracts of presentations at key conferences on calcified tissues

ba0001pp227 | Cell biology: osteoclasts and bone resorption | ECTS2013

RANKL immobilized on β-TCP induces and maintains osteoclast formation

Choy John , Hofstetter Wilhelm , Klenke Frank M

β-tricalcium phosphate (β-TCP) biomaterials have been approved for the repair of osseous defects. However, in large defects, the substitution of biomaterial by authentic bone is inadequate to provide sufficient long-term mechanical stability. We aimed to develop composites of β-TCP ceramics and receptor activator of nuclear factor κ-B ligand (RANKL) to enhance the formation of osteoclasts thereby stimulating material resorption. RANKL was immobilized on &#9...